Among hundreds of cannabinoids, delta-8-tetrahydrocannabinol (delta-8-THC, Δ8-THC) has rapidly risen in popularity among consumers of cannabis products. Delta-8-THC is a chemical analog of delta-9-THC, the molecule that produces the experience of being high when using cannabis . Delta-8-THC differs in the molecular structure from delta-9-THC. Due to its altered structure, delta-8-THC has a lower affinity for the CB1 receptor and therefore has a lower psychotropic potency than delta-9-THC . Delta-8-THC is found naturally in Cannabis, though at substantially lower concentrations than delta-9-THC.
In a recent study, (Kruger) most delta-8-THC users experienced a lot or a great deal of relaxation (71%); euphoria (68%) and pain relief (55%) and did not experience anxiety (74%) or paranoia (83%). The second most common theme was the therapeutic effect or benefit from delta-8-THC, participants’ responses containing this theme included: “It is like “lite” Delta 9. I can focus and work more with Delta 8 than Delta 9. It helps my pains and relaxation and I feel more able. Depending on the strain it has taken the place of melatonin for sleep.”; “As with any newer drug with limited study, care should be taken with its use. But I’ve personally found it immensely useful and therapeutic, with management of anxiety and sleep issues.
Delta-8-THC may provide much of the experiential benefits of delta-9-THC with lesser adverse effects. Future systematic research is needed to confirm participant reports, although these studies are hindered by the legal statuses of both delta-8-THC and delta-9-THC.